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Article

Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.

Developmental biology - 1 Nov 2014

Hou Congzhe, Ding Lingcui, Zhang Jian, Jin Yecheng, Sun Chen, Li Zhenzu, Sun Xiaoyang, Zhang Tingting, Zhang Aizhen, Li Huashun, Gao Jiangang

Abstract excerpt

Lgl1 was initially identified as a tumour suppressor in flies and is characterised as a key regulator of epithelial polarity and asymmetric cell division. A previous study indicated that More-Cre-mediated Lgl1 knockout mice exhibited significant brain dysplasia and died within 24h after birth. To overcome early neonatal lethality, we generated Lgl1 conditional knockout mice mediated by Pax2-Cre, which is...

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Identifiers

PMID: 25050931
DOI: 10.1016/j.ydbio.2014.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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