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CYP2C19 genotype-phenotype correlation: current insights and unanswered questions

1 Dec 2024

Abstract excerpt

Abstract The CYP2C19 enzyme is implicated in the metabolism of several clinically used drugs. Its phenotype is usually predicted by genotyping and indicates the expected enzymatic activity for each patient. However, with a few exceptions, CYP2C19 genotyping has not resulted in a reliable prediction of the metabolizer status, since most of the evidence currently available for this prediction comes from research...

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PMID: 39663234
DOI: 10.1515/dmpt-2024-0093

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