Article
NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia.
The pharmacogenomics journal - 1 Nov 2016
Liang D-C, Yang C-P, Liu H-C, Jaing T-H, Chen S-H, Hung I-J, Yeh T-C, Lin T-H, Lai C-L, Lai C-Y, Shih L-Y
Abstract excerpt
A recent study identified a variant of the NUDT15 gene (rs116855232 C>T) associated with intolerance to thiopurine in Korean patients with Crohn's disease. This study prompted us to substantiate the finding in a Taiwanese population. Four hundred and four children with acute lymphoblastic leukemia (ALL), and 100 adults with chronic immune thrombocytopenic purpura or localized lymphoma having normal bone marrow...
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