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Article

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet

27 Oct 2015

Abstract excerpt

PAX4 is a key regulator of pancreatic islet development whilst in adult acute overexpression protects β-cells against stress-induced apoptosis and stimulates proliferation. Nonetheless, sustained PAX4 expression promotes β-cell dedifferentiation and hyperglycemia, mimicking β-cell failure in diabetic patients. Herein, we study mechanisms that allow stringent PAX4 regulation endowing favorable β-cell adaptation in...

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PMID: 26503027
DOI: 10.1038/srep15672

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