Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multistep carcinogenesis: a chain reaction of aneuploidizations.

Cell cycle (Georgetown, Tex.) - 1 Jan 2000

Duesberg Peter, Li Ruhong

Abstract excerpt

Carcinogenesis is a multistep process in which new, parasitic and polymorphic cancer cells evolve from a single, normal diploid cell. This normal cell is converted to a prospective cancer cell, alias "initiated", either by a carcinogen or spontaneously. The initiated cell typically does not have a new distinctive phenotype yet, but evolves spontaneously--over months to decades--to a clinical cancer. The cells of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Cell Transformation, Neoplastic
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Eukaryotic Cells

Share to Gene Expression Regulation, Neoplastic

Share to Mitosis

Share to Mutation

Share to Neoplasms

Source

Identifiers

PMID: 12734426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multistep carcinogenesis: a chain reaction of aneuploidizations.PMID 12734426Read ↗

Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells.Semantic proximity Read ↗

Aneuploidy, the somatic mutation that makes cancer a species of its own.Semantic proximity Read ↗

How aneuploidy may cause cancer and genetic instability.Semantic proximity Read ↗

How aneuploidy affects metabolic control and causes cancer.Semantic proximity Read ↗

Is carcinogenesis a form of speciation?Semantic proximity Read ↗

Polyploidy, aneuploidy and the evolution of cancer.Semantic proximity Read ↗

On the karyotypic origin and evolution of cancer cells.Semantic proximity Read ↗

The chromosomal basis of cancer.Semantic proximity Read ↗

Mutations and aneuploidy: co-conspirators in cancer?Semantic proximity Read ↗

Destructive cycles: the role of genomic instability and adaptation in carcinogenesis.Semantic proximity Read ↗

Aneuploidy as a cancer vulnerabilitySemantic proximity Read ↗

Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.