Article
Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer.
Journal of cellular physiology - 1 May 2009
Ye Christine J, Stevens Joshua B, Liu Guo, Bremer Steven W, Jaiswal Aruna S, Ye Karen J, Lin Ming-Fong, Lawrenson Lesley, Lancaster Wayne D, Kurkinen Markku, Liao Joshua D, Gairola C Gary, Shekhar Malathy P V, Narayan Satya, Miller Fred R, Heng Henry H Q
Abstract excerpt
Cancer progression represents an evolutionary process where overall genome level changes reflect system instability and serve as a driving force for evolving new systems. To illustrate this principle it must be demonstrated that karyotypic heterogeneity (population diversity) directly contributes to tumorigenicity. Five well characterized in vitro tumor progression models representing various types of cancers...
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