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Article

Is carcinogenesis a form of speciation?

Cell cycle (Georgetown, Tex.) - 1 Jul 2011

Duesberg Peter, Mandrioli Daniele, McCormack Amanda, Nicholson Joshua M

Abstract excerpt

Since cancers have individual clonal karyotypes, are immortal and evolve from normal cells treated by carcinogens only after exceedingly long latencies of many months to decades-we deduce that carcinogenesis may be a form of speciation. This theory proposes that carcinogens initiate carcinogenesis by causing aneuploidy, i.e., losses or gains of chromosomes. Aneuploidy destabilizes the karyotype, because it...

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Identifiers

PMID: 21666415
DOI: 10.4161/cc.10.13.16352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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