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Article

Multiclonal tumor origin: Evidence and implications

6 May 2018

Abstract excerpt

An accurate understanding of the clonal origins of tumors is critical for designing effective strategies to treat or prevent cancer and for guiding the field of cancer risk assessment. The intent of this review is to summarize evidence of multiclonal tumor origin and, thereby, contest the commonly held assumption of monoclonal tumor origin. This review describes relevant studies of X chromosome inactivation,...

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Identifiers

PMID: 30115427
DOI: 10.1016/j.mrrev.2018.05.001

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