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Immortality of cancers: a consequence of inherent karyotypic variations and selections for autonomy.

Cell cycle (Georgetown, Tex.) - 1 Mar 2013

Duesberg Peter, McCormack Amanda

Abstract excerpt

Immortality is a common characteristic of cancers, but its origin and purpose are still unclear. Here we advance a karyotypic theory of immortality based on the theory that carcinogenesis is a form of speciation. Accordingly, cancers are generated from normal cells by random karyotypic rearrangements and selection for cancer-specific reproductive autonomy. Since such rearrangements unbalance long-established...

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PMID: 23388461
DOI: 10.4161/cc.23720
PMCID: PMC3610726

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