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Article

The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p.

BMC biochemistry - 1 Jan 2001

Zhou C, Seibert V, Geyer R, Rhee E, Lyapina S, Cope G, Deshaies R J, Wolf D A

Abstract excerpt

BACKGROUND: The function of the fission yeast cullins Pcu1p and Pcu4p requires modification by the ubiquitin-related peptide Ned8p. A recent report by Lyapina et al. shows that the COP9/signalosome (CSN), a multifunctional eight subunit complex, regulates Ned8p modification of Pcu1p. Disruption of caa1/csn1, which encodes subunit 1 of the putative S. pombe CSN, results in accumulation of Pcu1p exclusively in the...

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PMID: 11504566
DOI: 10.1186/1471-2091-2-7
PMCID: PMC37391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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