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Article

CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα.

Nucleic acids research - 29 Jan 2016

Kandala Divya T, Mohan Nimmy, A Vivekanand, A P Sudheesh, G Reshmi, Laishram Rakesh S

Abstract excerpt

Almost all eukaryotic mRNAs have a poly (A) tail at the 3'-end. Canonical PAPs (PAPα/γ) polyadenylate nuclear pre-mRNAs. The recent identification of the non-canonical Star-PAP revealed specificity of nuclear PAPs for pre-mRNAs, yet the mechanism how Star-PAP selects mRNA targets is still elusive. Moreover, how Star-PAP target mRNAs having canonical AAUAAA signal are not regulated by PAPα is unclear. We...

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PMID: 26496945
DOI: 10.1093/nar/gkv1074
PMCID: PMC4737136

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