Article
Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates.
BMC genomics - 24 Oct 2015
Black P A, de Vos M, Louw G E, van der Merwe R G, Dippenaar A, Streicher E M, Abdallah A M, Sampson S L, Victor T C, Dolby T, Simpson J A, van Helden P D, Warren R M, Pain A
Abstract excerpt
BACKGROUND: Whole genome sequencing has revolutionised the interrogation of mycobacterial genomes. Recent studies have reported conflicting findings on the genomic stability of Mycobacterium tuberculosis during the evolution of drug resistance. In an age where whole genome sequencing is increasingly relied upon for defining the structure of bacterial genomes, it is important to investigate the reliability of next...
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