Article
Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints.
PloS one - 12 Oct 2009
Niemann Stefan, Köser Claudio U, Gagneux Sebastien, Plinke Claudia, Homolka Susanne, Bignell Helen, Carter Richard J, Cheetham R Keira, Cox Anthony, Gormley Niall A, Kokko-Gonzales Paula, Murray Lisa J, Rigatti Roberto, Smith Vincent P, Arends Felix P M, Cox Helen S, Smith Geoff, Archer John A C
Abstract excerpt
BACKGROUND: Mycobacterium tuberculosis complex (MTBC), the causative agent of tuberculosis (TB), is characterized by low sequence diversity making this bacterium one of the classical examples of a genetically monomorphic pathogen. Because of this limited DNA sequence variation, routine genotyping of clinical MTBC isolates for epidemiological purposes relies on highly discriminatory DNA fingerprinting methods...
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