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Article

The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry.

Development (Cambridge, England) - 1 Dec 2015

Endicott S Joseph, Basu Basudha, Khokha Mustafa, Brueckner Martina

Abstract excerpt

Vertebrate left-right (LR) asymmetry originates at a transient left-right organizer (LRO), a ciliated structure where cilia play a crucial role in breaking symmetry. However, much remains unknown about the choreography of cilia biogenesis and resorption at this organ. We recently identified a mutation affecting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient with congenital heart...

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Source

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Identifiers

PMID: 26493400
DOI: 10.1242/dev.126953
PMCID: PMC4712839

Genes

NEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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