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Article

FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2009

Hong Sung-Kook, Dawid Igor B

Abstract excerpt

Establishment of left-right asymmetry in vertebrates requires nodal, Wnt-PCP and FGF signaling and involves ciliogenesis in a laterality organ. Effector genes through which FGF signaling affects laterality have not been described. We isolated the zebrafish ier2 and fibp1 genes as FGF target genes and show that their protein products interact. Knock down of these factors interferes with establishment of organ...

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Identifiers

PMID: 19164561
DOI: 10.1073/pnas.0812880106
PMCID: PMC2650137

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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