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Article

Defects in ciliary localization of Nek8 is associated with cystogenesis.

Pediatric nephrology (Berlin, Germany) - 1 Mar 2008

Trapp Melissa L, Galtseva Alevtina, Manning Danielle K, Beier David R, Rosenblum Norman D, Quarmby Lynne M

Abstract excerpt

Mutations in the human NIMA (Never in Mitosis gene A)-related kinase 8 (Nek8) are associated with a rare form of the juvenile renal cystic disease, nephronophthisis type 9, and mutations in murine Nek8 cause renal cysts in jck mice. Cystogenesis involves dysfunctional ciliary signaling, and we ha...

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Source

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Identifiers

PMID: 18189147
DOI: 10.1007/s00467-007-0692-y
PMCID: PMC6890203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18189147-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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