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Article

ZIC3 in Heterotaxy.

Advances in experimental medicine and biology - 1 Jan 2018

Bellchambers Helen M, Ware Stephanie M

Abstract excerpt

Mutation of ZIC3 causes X-linked heterotaxy, a syndrome in which the laterality of internal organs is disrupted. Analysis of model organisms and gene expression during early development suggests ZIC3-related heterotaxy occurs due to defects at the earliest stage of left-right axis formation. Although there are data to support abnormalities of the node and cilia as underlying causes, it is unclear at the molecular...

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Identifiers

PMID: 29442328
DOI: 10.1007/978-981-10-7311-3_15
PMCID: PMC8445495

Genes

ZIC3

Provenance

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