Article
Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.
BioMed research international - 1 Jan 2015
Olsen Daniel S, Goar Wesley A, Nichols Brandt A, Bailey K Tyson, Christensen S Loyd, Merriam Kayla R, Reynolds Paul R, Wilson Eric, Weber K Scott, Bridgewater Laura C
Abstract excerpt
We recently identified a nuclear variant of the BMP2 growth factor, called nBMP2. In an effort to understand the function of this variant protein, we generated a mouse line in which BMP2 is expressed and functions normally, but nBMP2 is excluded from the nucleus. This novel mutation allows the study of nBMP2 without compromising BMP2 function. To determine whether nBMP2 plays a role in immune function, we...
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