Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

Nature medicine - 1 Nov 1997

Iotsova V, Caamaño J, Loy J, Yang Y, Lewin A, Bravo R

Abstract excerpt

The nfkb1 and nfkb2 genes encode closely related products regulating immune and inflammatory responses. Their role during development and differentiation remains unclear. The generation of nfkb1 null mice (p50-/-) resulted in altered immune responses, but had no effect on development. Similarly,...

Topics

Animals
Bone Remodeling
Cell Differentiation
Flow Cytometry
Hematopoietic Stem Cells
Mice
Mice, Knockout
Models, Biological
NF-kappa B
NF-kappa B p50 Subunit
NF-kappa B p52 Subunit
Osteoclasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteopetrosis

Phenotype

Source

Identifiers

PMID: 9359707
DOI: 10.1038/nm1197-1285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9359707-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.PMID 9359707Read ↗

Critical Roles of NF-κB Signaling Molecules in Bone Metabolism Revealed by Genetic Mutations in Osteopetrosis.Semantic proximity Read ↗

A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".Semantic proximity Read ↗

p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout mice.Semantic proximity Read ↗

Lessons learned from molecular defects in nuclear factor kappaB dependent signaling.Semantic proximity Read ↗

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune ResponsesSemantic proximity Read ↗

Nuclear Factor-kappaB in Autoimmunity: Man and Mouse.Semantic proximity Read ↗

Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.Semantic proximity Read ↗

Advances in osteoclast biology: old findings and new insights from mouse modelsSemantic proximity Read ↗

Combined immune deficiency in a patient with a novel NFKB2 mutation.Semantic proximity Read ↗

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone lossSemantic proximity Read ↗

Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice.Semantic proximity Read ↗

Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.