Article
A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.
Arthritis and rheumatism - 1 May 2011
Abe Koichiro, Fuchs Helmut, Boersma Auke, Hans Wolfgang, Yu Philipp, Kalaydjiev Svetoslav, Klaften Matthias, Adler Thure, Calzada-Wack Julia, Mossbrugger Ilona, Rathkolb Birgit, Rozman Jan, Prehn Cornelia, Maraslioglu Miriam, Kametani Yoshie, Shimada Shin, Adamski Jerzy, Busch Dirk H, Esposito Irene, Klingenspor Martin, Wolf Eckhard, Wurst Wolfgang, Gailus-Durner Valerie, Katan Matilda, Marschall Susan, Soewarto Dian, Wagner Sibylle, de Angelis Martin Hrabě
Abstract excerpt
OBJECTIVE: It is difficult to identify a single causative factor for inflammatory arthritis because of the multifactorial nature of the disease. This study was undertaken to dissect the molecular complexity of systemic inflammatory disease, utilizing a combined approach of mutagenesis and systematic phenotype screening in a murine model. METHODS: In a large-scale N-ethyl-N-nitrosourea mutagenesis project, the...
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