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Article

A novel bone morphogenetic protein 2 mutant mouse, nBmp2NLS(tm), displays impaired intracellular Ca2+ handling in skeletal muscle.

BioMed research international - 1 Jan 2013

Bridgewater Laura C, Mayo Jaime L, Evanson Bradley G, Whitt Megan E, Dean Spencer A, Yates Joshua D, Holden Devin N, Schmidt Alina D, Fox Christopher L, Dhunghel Saroj, Steed Kevin S, Adam Michael M, Nichols Caitlin A, Loganathan Sampath K, Barrow Jeffery R, Hancock Chad R

Abstract excerpt

We recently reported a novel form of BMP2, designated nBMP2, which is translated from an alternative downstream start codon and is localized to the nucleus rather than secreted from the cell. To examine the function of nBMP2 in the nucleus, we engineered a gene-targeted mutant mouse model (nBmp2NLS(tm)) in which nBMP2 cannot be translocated to the nucleus. Immunohistochemistry demonstrated the presence of nBMP2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24369527
DOI: 10.1155/2013/125492
PMCID: PMC3863484

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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