Article
The BMP2 nuclear variant, nBMP2, is expressed in mouse hippocampus and impacts memory.
Scientific reports - 18 Apr 2017
Cordner Ryan D, Friend Lindsey N, Mayo Jaime L, Badgley Corinne, Wallmann Andrew, Stallings Conrad N, Young Peter L, Miles Darla R, Edwards Jeffrey G, Bridgewater Laura C
Abstract excerpt
The novel nuclear protein nBMP2 is synthesized from the BMP2 gene by translational initiation at an alternative start codon. We generated a targeted mutant mouse, nBmp2NLStm, in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of nBMP2 while still allowing the normal synthesis and secretion of the BMP2 growth factor. These mice exhibit abnormal muscle function due to...
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