Article
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2007
Tucker Elena, O'Donnell Kristy, Fuchsberger Martina, Hilton Adrienne A, Metcalf Donald, Greig Kylie, Sims Natalie A, Quinn Julian M, Alexander Warren S, Hilton Douglas J, Kile Benjamin T, Tarlinton David M, Starr Robyn
Abstract excerpt
The noncanonical NF-kappaB pathway regulates the development and function of multiple organs and cell lineages. We have generated mice harboring a novel mutation in Nfkb2 that prevents the processing of the inhibitory precursor, p100, into the active subunit, p52. Mutant mice express a complex phenotype with abnormalities in a variety of tissues, and with a spectrum that is more severe than in mice carrying a...
Topics
- Animals
- B-Lymphocytes
- Female
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- NF-kappa B p52 Subunit
- Osteoclasts
- Pedigree
- T-Lymphocytes
- Transcription Factor RelA