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Article

Stability of blocked replication forks in vivo.

Nucleic acids research - 29 Jan 2016

Mettrick Karla A, Grainge Ian

Abstract excerpt

Replication of chromosomal DNA must be carried out to completion in order for a cell to proliferate. However, replication forks can stall during this process for a variety of reasons, including nucleoprotein 'roadblocks' and DNA lesions. In these circumstances the replisome copying the DNA may disengage from the chromosome to allow various repair processes to restore DNA integrity and enable replication to...

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Identifiers

PMID: 26490956
DOI: 10.1093/nar/gkv1079
PMCID: PMC4737137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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