Article
Maintaining replication fork integrity in UV-irradiated Escherichia coli cells.
DNA repair - 1 Sept 2008
Rudolph Christian J, Upton Amy L, Lloyd Robert G
Abstract excerpt
In dividing cells, the stalling of replication fork complexes by impediments to DNA unwinding or by template imperfections that block synthesis by the polymerase subunits is a serious threat to genomic integrity and cell viability. What happens to stalled forks depends on the nature of the offending obstacle. In UV-irradiated Escherichia coli cells DNA synthesis is delayed for a considerable period, during which...
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