Article
Replication fork reversal after replication-transcription collision.
PLoS genetics - 1 Jan 2012
De Septenville Anne L, Duigou Stéphane, Boubakri Hasna, Michel Bénédicte
Abstract excerpt
Replication fork arrest is a recognized source of genetic instability, and transcription is one of the most prominent causes of replication impediment. We analyze here the requirement for recombination proteins in Escherichia coli when replication-transcription head-on collisions are induced at a specific site by the inversion of a highly expressed ribosomal operon (rrn). RecBC is the only recombination protein...
Topics
- Bacterial Proteins
- DNA Fragmentation
- DNA Helicases
- DNA Replication
- DNA, Cruciform
- Escherichia coli
- Escherichia coli Proteins
- Exodeoxyribonuclease V
- Exodeoxyribonucleases
- Holliday Junction Resolvases
- Homologous Recombination
- Methyltransferases
- Mutation
- Rec A Recombinases
- Transcription, Genetic