Article
RecQ helicases and cellular responses to DNA damage.
Mutation research - 30 Nov 2002
Wu Leonard, Hickson Ian D
Abstract excerpt
The faithful replication of the genome is essential for the survival of all organisms. It is not surprising therefore that numerous mechanisms have evolved to ensure that duplication of the genome occurs with only minimal risk of mutation induction. One mechanism of genome destabilization is replication fork demise, which can occur when a translocating fork meets a lesion or adduct in the template. Indeed, the...
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