Article
A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Oct 2015
Kedar Girish H, Munch Anders S, van Weering Jan R T, Malsam Jörg, Scheutzow Andrea, de Wit Heidi, Houy Sébastien, Tawfik Bassam, Söllner Thomas H, Sørensen Jakob B, Verhage Matthijs
Abstract excerpt
Synaptotagmin-1 (Syt1) is the principal Ca(2+) sensor for vesicle fusion and is also essential for vesicle docking in chromaffin cells. Docking depends on interactions of the Syt1-C2B domain with the t-SNARE SNAP25/Syntaxin1 complex and/or plasma membrane phospholipids. Here, we investigated the role of the positively charged "bottom" region of the C2B domain, proposed to help crosslink membranes, in vesicle...
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