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Article

Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.

Biophysical journal - 3 Jun 2025

Tsemperouli Maria, Cheppali Sudheer Kumar, Rivera-Molina Félix, Chetrit David, Landajuela Ane, Toomre Derek, Karatekin Erdem

Abstract excerpt

Synaptotagmin-1 (Syt1) is a major calcium sensor for rapid neurotransmitter release in neurons and hormone release in many neuroendocrine cells. It possesses two tandem cytosolic C2 domains that bind calcium, negatively charged phospholipids, and the neuronal SNARE complex. Calcium binding to Syt1 triggers exocytosis, but how this occurs is not well understood. Syt1 has additional roles in docking dense-core...

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Identifiers

PMID: 39719826
DOI: 10.1016/j.bpj.2024.12.023
PMCID: PMC12256845

Genes

C2

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Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.PMID 39719826Read ↗

Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1Semantic proximity Read ↗

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Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.Semantic proximity Read ↗

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).Semantic proximity Read ↗

The C2 domains of synaptotagmin--partners in exocytosis.Semantic proximity Read ↗

Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation.Semantic proximity Read ↗

Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.Semantic proximity Read ↗

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Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion.Semantic proximity Read ↗

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