Article
Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Sept 2013
Mohrmann Ralf, de Wit Heidi, Connell Emma, Pinheiro Paulo S, Leese Charlotte, Bruns Dieter, Davletov Bazbek, Verhage Matthijs, Sørensen Jakob B
Abstract excerpt
SNARE complex assembly constitutes a key step in exocytosis that is rendered Ca(2+)-dependent by interactions with synaptotagmin-1. Two putative sites for synaptotagmin binding have recently been identified in SNAP-25 using biochemical methods: one located around the center and another at the C-terminal end of the SNARE bundle. However, it is still unclear whether and how synaptotagmin-1 × SNARE interactions at...
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