Article
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
The Journal of cell biology - 26 Dec 2011
Wang Zhao, Liu Huisheng, Gu Yiwen, Chapman Edwin R
Abstract excerpt
The synaptic vesicle protein synaptotagmin I (syt) promotes exocytosis via its ability to penetrate membranes in response to binding Ca(2+) and through direct interactions with SNARE proteins. However, studies using full-length (FL) membrane-embedded syt in reconstituted fusion assays have yielded conflicting results, including a lack of effect, or even inhibition of fusion, by Ca(2+). In this paper, we show that...
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