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Differential effect of genetic burden on disease phenotypes in Crohn's disease and ulcerative colitis: analysis of a North American cohort.

The American journal of gastroenterology - 1 Mar 2014

Ananthakrishnan Ashwin N, Huang Hailiang, Nguyen Deanna D, Sauk Jenny, Yajnik Vijay, Xavier Ramnik J

Abstract excerpt

OBJECTIVES: Crohn's disease (CD) and ulcerative colitis (UC) are chronic immunologically mediated diseases with a progressive relapsing remitting course. There is considerable heterogeneity in disease course and accurate prediction of natural history has been challenging. The phenotypic implication of increasing genetic predisposition to CD or UC is unknown. METHODS: The data source for our study was a...

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Cohort Studies
Colitis, Ulcerative
Crohn Disease
Nod2 Signaling Adaptor Protein
North America

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PMID: 24419484
DOI: 10.1038/ajg.2013.464
PMCID: PMC4225079

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NOD2

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