Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.

doi:10.1053/j.gastro.2014.12.030

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Article

Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.

Gastroenterology - 1 Apr 2015

Alonso Arnald, Domènech Eugeni, Julià Antonio, Panés Julián, García-Sánchez Valle, Mateu Pilar Nos, Gutiérrez Ana, Gomollón Fernando, Mendoza Juan L, Garcia-Planella Esther, Barreiro-de Acosta Manuel, Muñoz Fernando, Vera Maribel, Saro Cristina, Esteve Maria, Andreu Montserrat, Chaparro Maria, Manyé Josep, Cabré Eduard, López-Lasanta María, Tortosa Raül, Gelpí Josep Lluís, García-Montero Andrés C, Bertranpetit Jaume, Absher Devin, Myers Richard M, Marsal Sara, Gisbert Javier P

Abstract excerpt

BACKGROUND & AIMS: Crohn's disease is a highly heterogeneous inflammatory bowel disease comprising multiple clinical phenotypes. Genome-wide association studies (GWASs) have associated a large number of loci with disease risk but have not associated any specific genetic variants with clinical phenotypes. We performed a GWAS of clinical phenotypes in Crohn's disease. METHODS: We genotyped 576,818 single-nucleotide...

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PMID: 25557950
DOI: 10.1053/j.gastro.2014.12.030

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