Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.

International immunology - 1 Mar 2016

Kamimura Daisuke, Arima Yasunobu, Tsuruoka Mineko, Jiang Jing-Jing, Bando Hidenori, Meng Jie, Sabharwal Lavannya, Stofkova Andrea, Nishikawa Naoki, Higuchi Kotaro, Ogura Hideki, Atsumi Toru, Murakami Masaaki

Abstract excerpt

KDEL receptor 1 (KDELR1) regulates integrated stress responses (ISR) to promote naive T-cell survival in vivo. In a mouse line having nonfunctional KDELR1, T-Red (naive T-cell reduced) mice, polyclonal naive T cells show excessive ISR and eventually undergo apoptosis. However, breeding T-Red mice with TCR-transgenic mice bearing relatively high TCR affinity rescued the T-Red phenotype, implying a link between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to CD5 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to Homeostasis

Share to Immunologic Memory

Share to Lymphocyte Activation

Share to Receptors, Antigen, T-Cell

Share to Receptors, Peptide

Source

Identifiers

PMID: 26489882
DOI: 10.1093/intimm/dxv059

Genes

KDELR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.PMID 26489882Read ↗

KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.Semantic proximity Read ↗

The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.Semantic proximity Read ↗

Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells.Semantic proximity Read ↗

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.Semantic proximity Read ↗

Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes.Semantic proximity Read ↗

Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8 <sup>+</sup> T cell pathogenicity in non-obese diabetic miceSemantic proximity Read ↗

An Essential Role of the Avidity of T-Cell Receptor in Differentiation of Self-Antigen-reactive CD8+ T Cells.Semantic proximity Read ↗

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.Semantic proximity Read ↗

Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian agingSemantic proximity Read ↗

Learning to be tolerant: how T cells keep out of trouble.Semantic proximity Read ↗

Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection.Semantic proximity Read ↗

Peripheral residence of naïve CD4 T cells induces MHC class II-dependent alterations in phenotype and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.