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Article

An Essential Role of the Avidity of T-Cell Receptor in Differentiation of Self-Antigen-reactive CD8+ T Cells.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Apr 2016

Kondo Kenta, Fujiki Fumihiro, Nakajima Hiroko, Yatsukawa Erika, Morimoto Soyoko, Tatsumi Naoya, Nishida Sumiyuki, Nakata Jun, Oka Yoshihiro, Tsuboi Akihiro, Hosen Naoki, Oji Yusuke, Sugiyama Haruo

Abstract excerpt

Many studies demonstrated crucial roles of avidity of T-cell receptor (TCR) in T-cell fate. However, majority of these findings resulted from analysis of non-self-antigen-specific CD8 T cells, and little is known about roles of TCR avidity in the fate of self-antigen-specific CD8 T cells. Wilms tumor gene 1 (WT1) protein is a self-antigen most suitable for addressing this issue because WT1 protein is a highly...

Read the complete abstract on PubMed

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Share to Autoantigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Epitopes, T-Lymphocyte

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Share to Receptors, Antigen, T-Cell

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Identifiers

PMID: 26938946
DOI: 10.1097/CJI.0000000000000114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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