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Article

Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection.

Cell cycle (Georgetown, Tex.) - 15 Feb 2010

Paschalidis Nikolaos, Huggins Anthony, Rowbotham Nicola J, Furmanski Anna L, Crompton Tessa, Flower Roderick J, Perretti Mauro, D'Acquisto Fulvio

Abstract excerpt

We have recently shown that endogenous Annexin-A1 (AnxA1) plays a homeostatic regulatory role in mature T cells by modulating the strength of TCR signaling. In this study we investigated the role of endogenous AnxA1 in thymocyte maturation. Analysis of AnxA1(-/-) thymocyte populations at the immature CD4(-)CD8(-) double negative (DN) stage showed a proportional decrease in the DN1 and an increase in the DN3...

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PMID: 20139728

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