Learning to be tolerant: how T cells keep out of trouble.

Abstract excerpt

A pool of immature T cells with a seemingly unrestricted repertoire of antigen specificities is generated life-long in the thymus. Amongst these cells are, however, thymocytes that express a strongly self-reactive antigen receptor and hence hold the potential to trigger autoimmunity. To prevent such an outcome, the thymus employs several independent but functionally related strategies that act in parallel to...

Topics

• Autoimmunity
• Histocompatibility Antigens Class II
• Humans
• Immunity, Cellular
• Models, Immunological
• Mutation
• Self Tolerance
• T-Lymphocyte Subsets
• T-Lymphocytes, Regulatory
• Thymus Gland
• Transcription Factors