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Article

Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells.

BMC immunology - 9 Feb 2012

Tatari-Calderone Zohreh, Stojakovic Milica, Dewan Ramita, Le Bouder Gama, Jankovic Dragana, Vukmanovic Stanislav

Abstract excerpt

BACKGROUND: Thymic involution is a prominent characteristic of an aging immune system. When thymic function is reduced/absent, the peripheral T cell pool is subject to the laws of peripheral T cell homeostasis that favor survival/expansion of T cell receptors with relatively higher functional avidity for self-peptide/MHC complexes. Due to difficulties in assessing the TCR avidity in polyclonal population of T...

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Identifiers

PMID: 22321827
DOI: 10.1186/1471-2172-13-8
PMCID: PMC3305419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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