KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.

doi:10.1038/ncomms8474

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.

Nature communications - 17 Jun 2015

Kamimura Daisuke, Katsunuma Kokichi, Arima Yasunobu, Atsumi Toru, Jiang Jing-jing, Bando Hidenori, Meng Jie, Sabharwal Lavannya, Stofkova Andrea, Nishikawa Naoki, Suzuki Hironao, Ogura Hideki, Ueda Naoko, Tsuruoka Mineko, Harada Masaya, Kobayashi Junya, Hasegawa Takanori, Yoshida Hisahiro, Koseki Haruhiko, Miura Ikuo, Wakana Shigeharu, Nishida Keigo, Kitamura Hidemitsu, Fukada Toshiyuki, Hirano Toshio, Murakami Masaaki

Abstract excerpt

KDEL receptors are responsible for retrotransporting endoplasmic reticulum (ER) chaperones from the Golgi complex to the ER. Here we describe a role for KDEL receptor 1 (KDELR1) that involves the regulation of integrated stress responses (ISR) in T cells. Designing and using an N-ethyl-N-nitrosourea (ENU)-mutant mouse line, T-Red (naïve T-cell reduced), we show that a point mutation in KDELR1 is responsible for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bcl-2-Like Protein 11

Share to Eukaryotic Initiation Factor-2

Share to Homeostasis

Share to Immunologic Memory

Share to Mice, Inbred C3H

Share to Protein Phosphatase 1

Share to Receptors, Peptide

Source

Open in PubMed Open full text

Identifiers

PMID: 26081938
DOI: 10.1038/ncomms8474
PMCID: PMC4557295

Genes

KDELR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.PMID 26081938Read ↗

Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.Semantic proximity Read ↗

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.Semantic proximity Read ↗

Getting a grip on Thy-1 signalingSemantic proximity Read ↗

Par-4 overexpression impedes leukemogenesis in the Eµ-TCL1 leukemia model through downregulation of NF-κB signalingSemantic proximity Read ↗

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.Semantic proximity Read ↗

Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian agingSemantic proximity Read ↗

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.Semantic proximity Read ↗

Transgenic Expression of a Mutant Ribonuclease Regnase-1 in T Cells Disturbs T Cell Development and Functions.Semantic proximity Read ↗

The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformationSemantic proximity Read ↗

T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cellSemantic proximity Read ↗

Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence.Semantic proximity Read ↗

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.