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Article

JAK-2 V617F mutation increases heparanase procoagulant activity.

Thrombosis and haemostasis - 1 Jan 2016

Kogan Inna, Chap Dafna, Hoffman Ron, Axelman Elena, Brenner Benjamin, Nadir Yona

Abstract excerpt

Patients with polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) are at increased risk of arterial and venous thrombosis. In patients with ET a positive correlation was observed between JAK-2 V617F mutation, that facilitates erythropoietin receptor signalling, and thrombotic events, although the mechanism involved is not clear. We previously demonstrated that heparanase...

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PMID: 26489695
DOI: 10.1160/TH15-04-0320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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