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Article

Heparanase (HPSE) genetic variants as prognostic indicators in ovarian cancer: evidence from discovery and validation cohorts.

Molecular biology reports - 5 May 2026

de Melo Inês Guerra, Tavares Valéria, Savva-Bordalo Joana, Rei Mariana, Liz-Pimenta Joana, Pereira Deolinda, Medeiros Rui

Abstract excerpt

BACKGROUND: Heparanase uniquely cleaves heparan sulfate, the main component of the outer layer of endothelial cell plasma membranes, promoting tumour invasion and dissemination. However, it can also enhance tumour immune surveillance and clearance. heparanase's versatility extends to pro-thrombotic properties, such as the promotion of tissue factor release. Interestingly, elevated heparanase levels have been...

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Identifiers

PMID: 42084761
DOI: 10.1007/s11033-026-11891-y
PMCID: PMC13144214

Genes

HPSE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Heparanase (HPSE) genetic variants as prognostic indicators in ovarian cancer: evidence from discovery and validation cohorts.PMID 42084761Read ↗

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