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Article

Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2005

Okawa Takaomi, Naomoto Yoshio, Nobuhisa Tetsuji, Takaoka Munenori, Motoki Takayuki, Shirakawa Yasuhiro, Yamatsuji Tomoki, Inoue Hiroyasu, Ouchida Mamoru, Gunduz Mehmet, Nakajima Motowo, Tanaka Noriaki

Abstract excerpt

PURPOSE: Both heparanase and cyclooxygenase-2 (COX-2) are thought to play critical roles for tumor malignancy, including angiogenesis, although it is unknown about their relationship with each other in cancer progression. We hypothesized that they may link to each other on tumor angiogenesis. EXPERIMENTAL DESIGN: The expressions of heparanase and COX-2 in 77 primary human esophageal cancer tissues were assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16299228
DOI: 10.1158/1078-0432.CCR-05-1103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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