Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heparanase wildtype is associated with a reduced incidence of transplant-associated systemic vasculopathies.

Hematology/oncology and stem cell therapy - 4 Apr 2023

Mueckenhausen Raphaela, Föll Jürgen, Kleinschmidt Katharina, Tröger Anja, Malaisé Muriel, Wolff Daniel, Holler Ernst, Matthes Marie, Heise Tilman, Sommer Gunhild, Corbacioglu Selim

Abstract excerpt

Some of the early complications of hematopoietic stem cell transplantation (HSCT) concerning the small vessels can be summarized as transplant-associated systemic vasculopathies (TASV). One enzyme known to play a major role in inflammation, tissue remodeling, and repair processes as well as tumor metastasis is heparanase (HPSE). HPSE genetic variants have recently been associated with significant influence on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genotype
Share to Graft vs Host Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Incidence

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 34848216
DOI: 10.1016/j.hemonc.2021.10.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heparanase wildtype is associated with a reduced incidence of transplant-associated systemic vasculopathies.PMID 34848216Read ↗

Discrepancy between recipient and donor rs4364254 heparanase single nucleotide polymorphism impacts graft-versus-host disease after allogeneic stem cell transplant.Semantic proximity Read ↗

Heparanase polymorphisms: influence on incidence of hepatic sinusoidal obstruction syndrome in children undergoing allogeneic hematopoietic stem cell transplantation.Semantic proximity Read ↗

Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors.Semantic proximity Read ↗

CMV Seropositive Status Increases Heparanase SNPs Regulatory Activity, Risk of Acute GVHD and Yield of CD34+ Cell Mobilization.Semantic proximity Read ↗

Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.Semantic proximity Read ↗

Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP.Semantic proximity Read ↗

The HPSE Gene Insulator-A Novel Regulatory Element That Affects Heparanase Expression, Stem Cell Mobilization, and the Risk of Acute Graft versus Host Disease.Semantic proximity Read ↗

Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.Semantic proximity Read ↗

Heparanase (HPSE) genetic variants as prognostic indicators in ovarian cancer: evidence from discovery and validation cohorts.Semantic proximity Read ↗

Polymorphisms and a haplotype in heparanase gene associations with the progression and prognosis of gastric cancer in a northern Chinese population.Semantic proximity Read ↗

Mechanism of HPSE Gene SNPs Function: From Normal Processes to Inflammation, Cancerogenesis and Tumor Progression.Semantic proximity Read ↗

Reassessing HPSE in Ovarian Cancer: Beneficial After All?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.