Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.

Matrix biology : journal of the International Society for Matrix Biology - 1 Sept 2016

Ramani Vishnu C, Vlodavsky Israel, Ng Mary, Zhang Yi, Barbieri Paola, Noseda Alessandro, Sanderson Ralph D

Abstract excerpt

High heparanase expression is associated with enhanced tumor growth, angiogenesis, and metastasis in many types of cancer. However, the mechanisms driving high heparanase expression are not fully understood. In the present study, we discovered that drugs used in the treatment of myeloma upregulate heparanase expression. Frontline anti-myeloma drugs, bortezomib and carfilzomib activate the nuclear factor-kappa B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Bortezomib

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Doxorubicin

Share to Enzyme Induction

Share to Glucuronidase

Share to Melanoma

Share to Melphalan

Share to Oligopeptides

Source

Open in PubMed Open full text

Identifiers

PMID: 27016342
DOI: 10.1016/j.matbio.2016.03.006
PMCID: PMC5033659

Genes

HGF
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.PMID 27016342Read ↗

Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.Semantic proximity Read ↗

Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype.Semantic proximity Read ↗

Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells.Semantic proximity Read ↗

Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myelomaSemantic proximity Read ↗

MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting HeparanaseSemantic proximity Read ↗

Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatinsSemantic proximity Read ↗

Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.Semantic proximity Read ↗

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.Semantic proximity Read ↗

Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.Semantic proximity Read ↗

Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies.Semantic proximity Read ↗

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myelomaSemantic proximity Read ↗

Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.