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Article

Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.

Journal of leukocyte biology - 1 Aug 2009

Ostrovsky Olga, Korostishevsky Michael, Shafat Itay, Mayorov Margarita, Ilan Neta, Vlodavsky Israel, Nagler Arnon

Abstract excerpt

Heparanase is an endo-beta-glucuronidase that specifically cleaves the saccharide chains of heparan sulfate proteoglycans. Heparanase plays important roles in processes such as angiogenesis, tumor metastasis, tissue repair and remodeling, inflammation and autoimmunity. Genetic variations of the heparanase gene (HPSE) have been associated with heparanase transcription level. The present study was undertaken to...

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Source

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Identifiers

PMID: 19406828
DOI: 10.1189/jlb.1208735
PMCID: PMC2796676

Genes

HPSE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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