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Article

Cell populations can use aneuploidy to survive telomerase insufficiency

22 Oct 2015

Abstract excerpt

Telomerase maintains ends of eukaryotic chromosomes, telomeres. Telomerase loss results in replicative senescence and a switch to recombination-dependent telomere maintenance. Telomerase insufficiency in humans leads to telomere syndromes associated with premature ageing and cancer predisposition. Here we use yeast to show that the survival of telomerase insufficiency differs from the survival of telomerase loss...

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PMID: 26489519
DOI: 10.1038/ncomms9664

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