Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unraveling the stepwise maturation of the yeast telomerase including a Cse1 and Mtr10 mediated quality control checkpoint.

Scientific reports - 12 Nov 2021

Hirsch Anna Greta, Becker Daniel, Lamping Jan-Philipp, Krebber Heike

Abstract excerpt

Telomerases elongate the ends of chromosomes required for cell immortality through their reverse transcriptase activity. By using the model organism Saccharomyces cerevisiae we defined the order in which the holoenzyme matures. First, a longer precursor of the telomerase RNA, TLC1 is transcribed and exported into the cytoplasm, where it associates with the protecting Sm-ring, the Est and the Pop proteins. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Nucleocytoplasmic Transport Proteins

Share to RNA-Binding Proteins

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 34773052
DOI: 10.1038/s41598-021-01599-3
PMCID: PMC8590012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unraveling the stepwise maturation of the yeast telomerase including a Cse1 and Mtr10 mediated quality control checkpoint.PMID 34773052Read ↗

TLC1 RNA nucleo‐cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeresSemantic proximity Read ↗

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-InSemantic proximity Read ↗

Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomeraseSemantic proximity Read ↗

The many faces of the helicase RTEL1 at telomeres and beyond.Semantic proximity Read ↗

Unravelling the Intricacies of Telomere Replication: A Molecular ConundrumSemantic proximity Read ↗

Telomerase RNA processing: Implications for human health and diseaseSemantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

It all comes together at the ends: telomerase structure, function, and biogenesis.Semantic proximity Read ↗

Mitochondria, Telomeres and Telomerase SubunitsSemantic proximity Read ↗

A new telomerase RNA element that is critical for telomere elongation.Semantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.