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Article

Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion

27 Mar 2015

Abstract excerpt

The causal role of aneuploidy in cancer initiation remains under debate since mutations of euploidy-controlling genes reduce cell fitness but aneuploidy strongly associates with human cancers. Telomerase activation allows immortal growth by stabilizing telomere length, but its role in aneuploidy survival has not been characterized. Here, we analyze the response of primary human cells and murine hematopoietic stem...

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Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 25820263
DOI: 10.15252/embj.201490070

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