Article
Natural proteome diversity links aneuploidy tolerance to protein turnover.
Nature - 1 Jun 2024
Muenzner Julia, Trébulle Pauline, Agostini Federica, Zauber Henrik, Messner Christoph B, Steger Martin, Kilian Christiane, Lau Kate, Barthel Natalie, Lehmann Andrea, Textoris-Taube Kathrin, Caudal Elodie, Egger Anna-Sophia, Amari Fatma, De Chiara Matteo, Demichev Vadim, Gossmann Toni I, Mülleder Michael, Liti Gianni, Schacherer Joseph, Selbach Matthias, Berman Judith, Ralser Markus
Abstract excerpt
Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions and allows the generalizability of laboratory findings to be assessed. One notable discovery made in natural isolates of Saccharomyces cerevisiae is that aneuploidy-an imbalance in chromosome copy numbers-is frequent1,2 (around 20%), which seems to contradict the substantial fitness costs and transient...
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