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Article

Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice.

Journal of vascular surgery - 1 Nov 2016

El-Sayed Osama M, Dewyer Nicholas A, Luke Catherine E, Elfline Megan, Laser Adriana, Hogaboam Cory, Kunkel Steven L, Henke Peter K

Abstract excerpt

BACKGROUND: Deletion of Toll-like receptor 9 (Tlr9) signaling, which is important for sterile inflammatory processes, results in impaired resolution of venous thrombosis (VT) in mice. The purpose of this study was to determine if deletion of Tlr9 affected sterile necrosis, apoptosis, and neutrophil extracellular trap (NET) production in VT. METHODS: Stasis and nonstasis murine models of VT were used in wild-type...

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Source

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Identifiers

PMID: 26482993
DOI: 10.1016/j.jvs.2015.08.070
PMCID: PMC4834067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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